"How (and why) did human beings come to be able to know so much about how the Universe works?" — Ron Besdansky
It is an interesting question. However it contains the presumption that we humans 'know' a lot about how the Universe works.
I don't think this is really true, and I am not convinced that we have much of an ability to actively know much at all, other than what we are destined to know, and perhaps what we allow ourselves to feel. There are some aspects of human thought; that might well be free to think or feel about how the Universe appears to us, but I think these are poorly understood.
We are limited in our knowledge by our assumptions, these assumptions confine our Universe to a particular form, Cosmology, singularity, bang, evolution, Newtonian mechanics, Relativity, Freud, Marx, quantum mechanics, math. All of these coordinates have arisen from relatively simple basic concepts and the 'so much' that we know lies only in the 'evolution' of simple concepts. The complexity of the modern car may be traced to the simple principles of combustion and perhaps the wheel. It is possible to apply an infinity of combinations to the binary of one and zero. Once can write human history in this language, yet the underlying initial concept is rather simple.
I feel that we know relatively little, (as yet nothing of applied practical value) and as yet are simply dealing with the admittedly complex evolution of several simple and universal concepts. We have no more than a handful of apparently fundamental truths out of which our knowledge has evolved, and several fundamental truths are still lacking.
The evolution of reasoned analysis is very much in its infancy, it has ejaculated onto the stage of cosmic evolution in a burst of apparent glory and complexity, however it has yet to be disciplined in any real sense. The evidence for this is obvious in the current state of man's purportedly organised systems, which have arisen out of this so called 'knowing'.
If indeed I know how to tie my shoelaces, I should rightly be expected to complete the task with some precision and efficiency. Mankind's political, philosophical, technical and social systems are neither precise nor efficient, and the state or threat to global ecology would imply that his 'knowledge' of science is not yet a knowledge, but simply an engagement of sorts the early stages of encounter. We may well be aware of shoes and the laces and how they might possibly be tied, but as yet we have no knowledge of the task at hand. Political science is perhaps the best example of knowledge that has recently produced a Trump card.
True 'knowing' is in its infancy and one might ask if we are going to survive it? never mind evolve it into an efficient practicality.
I think old Socrates had the best response to knowledge, when he went looking for a wise man, he concluded the wisest to be the fool, who is at least 'aware' of the infinite basis of his ignorance.
M