Awareness in Molecules? Sorry - it isn't practical for me to respond to people individually so I will try to cover off a few points collectively.
There seems to be a fair amount of confusion in these various responses between consciousness and awareness. Awareness is not consciousness and at best is just one of several factors in achieving consciousness.
While I admit that it is unusual to invoke the suggestion of awareness in molecules, people are avoiding the issues raised if they try to dismiss the question by pretending that my OP is in some way trying to promote a God of the Gaps argument. It isn't, and if you run away from the points by using God as a way to deflect from the issue, I think you have lost the argument. This is a serious question, because the computational models which can be applied to a single molecule, or even a few of them, cannot get close to explaining homologous recombination.
Evolution tells us how something may have arisen, it doesn't tell us how a dynamic process is made to work in ever-changing circumstances.
I am not sure that an enzyme is just a catalyst, but they are observed doing things which go well beyond simple chemical matching/enabling. Think about just one of the steps involved....
- the breaks on both stands of the DNA molecule are rarely clean and often result in missing pieces that form gaps of long and varying lengths. Yet enzymes need to establish the size of a gap before attempting to repair each strand. In doing this they seem to go hunting for parts of a different strand of DNA that equates to the full sequence of the correct gene - a different template which is generally not just side by side with the break but potentially curled up in a completely different place.
Neither is this matching process just a case of finding the first nucleobase pair and then continuing from that random point - no - the active molecules in the process go looking for a complete sequence that is appropriate to the unbroken sections of DNA that remain on either side of the break. How does it make that assessment? We can do this with a brain, because we understand the scenario, the objective, and the significance of the coded sequences on the remaining strands of the DNA. How does the matching occur without such awareness?
I do not mind a purely chemical solution emerging, and I am certainly not promoting a God-based solution, but when decades of research fails to even get close to an answer, and what we see is not a fixed process but a variable/dynamic one - aiming for an outcome that we can describe as an objective that we can predict - then I think it is fair to ask where that level of sophistication comes from if it is not from traditional sources.
Basic observation shows that the behaviour of these chemicals is far from the scenario normally predicted by the mathematics of the physical laws, and the deterministic principles commonly applied. There seems to be an additional factor here which has not been identified and if the logic that we humans might apply to mimic what is happing through our manual efforts, can only be achieved by millions of brain cells - and yet it is happening with a handful of enzymes - then we are truly missing something profound.