Mediocre guys are invariably pitted against a challenge that they are unlikely to overcome.
Yet through cunning, or via strength, or via moral vicissitude, or through blood viscosity, they overcome the challenge. Otherwise the book is a fail. — god must be atheist
Crime and Punishment (Loser has illusions of grandeur, commits murder, can't hold it together, gets caught... what a loser)
Moby Dick (Losers stuck on a ship are taken by a ride by mad captain, a kind of loser, who holds grudge against a whale of all things. They all get screwed by Moby. Everyone dies except the narrator. Lady luck is on Ishmael's side.)
Grendel, John Gardner (The loser is a monster by birth, fated to be lonely because of his inheritance/identity, meets his fate by the hand of the hero, Beowulf, because he is really tired of it all)
Painted Bird (Loser is a lost child buffeted by the unspeakable depravities of war, tortured until morally cracked)
Death in Venice (Loser is a benign and depressed pedophile, who stays in Venice despite epidemic to stare at young boy. Loser dies of cholera)
Anna Karenina (Lady can't cope, throws herself in front of train)
Great Gatsby (Bunch of wealthy party dicks, winners, accidentally kill a woman while having a gay old time. Gatsby takes the blame and gets murdered. Can't enjoy bootlegged wealth when your dead.)
Requiem for a Dream (Folks make a bunch of life mistakes which cause them to spiral down the drain of life, now losers, to be further used and abused)
Irreversible (Lady gets brutally raped. Raper narrowly evades the act of vengeance while some misidentified person gets targeted and macerated)
1984 (Loser is stuck in a dystopic hell, lured into a trap of hope, only to be absolutely and finally broken by totalitarian control).
The screwball chaos of life, losers failing, winners failing, in strange circumstances, makes for some worthwhile reads/vids.