Well, there is historically a hard problem of motion, that was made worse when Newton discovered gravity, which to his dismay made no sense to him.
I think an appropriate way to look at these things is to see that they are all at bottom mysterious. As Schopenhauer said:
"The tendency to gravity in the stone is precisely as inexplicable as is thinking in the human brain, and so on this score, we could also infer a spirit in the stone. Therefore to these disputants [between 'spiritualists' and 'materialists'] I would say: you think you know a dead matter, that is, one that is completely passive and devoid of properties, because you imagine you really understand everything that you are able to reduce to mechanical effect. But… you are unable to reduce them… If matter can fall to earth without you knowing why, so can it also think without you knowing why… If your dead and purely passive matter can as heaviness gravitate, or as electricity attract, repel, and emit spark, so too as brain pulp can it think."
I think that is accurate perspective. Or take Locke:
Whether Matter may not be made by God to think is more than man can know. For I see no contradiction in it, that the first Eternal thinking Being, or Omnipotent Spirit, should, if he pleased, give to certain systems of created senseless matter, put together as he thinks fit, some degrees of sense, perception, and thought... it is no less than a contradiction to suppose matter (which is evidently in its own nature void of sense and thought) should be that Eternal first-thinking Being...Body, as far as we can conceive, being able only to strike and affect body, and motion, according to the utmost reach of our ideas, being able to produce nothing but motion; so that when we allow it to produce pleasure or pain, or the idea of a colour or sound, we are fain to quit our reason, go beyond our ideas, and attribute it wholly to the good pleasure of our Maker.
For, since we must allow He has annexed effects to motion which we can no way conceive motion able to produce, what reason have we to conclude that He could not order them as well to be produced in a subject we cannot conceive capable of them, as well as in a subject we cannot conceive the motion of matter can any way operate upon?
(Bold added).
I could add more from Hume, Priestley even Leibniz, and others.
So yeah, I think there is a deep mystery as regards to oxygen, gravity, mutations, liquidity, and virtually everything, on equal footing with consciousness.