why are all these medical professionals in support of the dominant narrative and dismissive of more balanced approaches? — dazed
There are multiple reasons why it seems that most medical professional are supporting the dominant narrative, — Book273
Astrazeneca vaccine wasn't put on hold because of safety concerns or lack of efficacy, there was just a production error. They mixed up ingredients at the facility. Irregardless its efficacy is lower than Pfizer and Moderna, so if I were you I'd go with one of those.Anti-vaccination sentiment (as it relates to COVID19) is tied to suspicions about the origins of the disease and the profitability of vaccines, as well as fears about it's safety.
But now that the Astra-Zeneca vaccine is being put on hold, at least one arm if opposition seems to have been vindicated.
What about the notion that the vaccine is a tool for extracting money from the population? How suspicious are you?
Astrazeneca vaccine wasn't put on hold because of safety concerns — aporiap
Irregardless its efficacy is lower than Pfizer and Moderna, so if I were you I'd go with one of those. — aporiap
EUA is not just a political stamp, it involves rigorous safety, manufacturing, and efficacy standards. The difference is in follow up safety requirement. FDA approval requires safety monitoring for at least 6 months post vaccination, EUA requires at least 2 month post vaccination safety monitoring. Both EUA and FDA approval involve the same efficacy requirement. Pfizer and moderna vaccines, have excellent safety profiles compared to other vaccines per data on thousands of vaccinated individuals. Pfizer just actually finished analyzing their 6 month monitoring results and are planning to apply for full BLA licensure soon. The risk at this point for taking the pfizer vaccine is demonstrably minimal; I figure it will be the same for Modernas given their safety profile in phase III.The vaccines have not been Approved by the US FDA; they are merely (politically) Authorized For Emergency Use. I'm not terminal/end-stage anything and have a proven alternative (masks, etc) – which mostly prevents the spread (re: none of the available vaccines have been shown to do this effectively) – to volunteering to be a guinea pig for Pfizer, Moderna, etc in mass-experiment public trials. I'm in no way anti-vaxx and not anti-science either; the public health exigencies are obvious, but I'll take my chances until 6-9 months more data comes in.
Thanks I wasn't aware. I've read some more now, and it looks like there was a statement issued on the 18th of March by the EMA safety committee: there is still no causal link between the vaccines and the clots and the frequency of clots in the study population is not more than one would expect in the general population. They still conclude the benefits outweigh the risks.It's on hold in some European countries due to coagulation issues.
The high efficacy of the Pfizer and Moderna vaccines reflects when their testing took place. All the vaccines are highly effective regarding severe illness or death from COVID 19.
That's great. That doesn't preclude the existing robust data on safety and efficacy up to 90 days.I was vaccinated the day before Christmas. I'm in a study looking at how long the antibodies last.
Thanks I wasn't aware. I've read some more now, and it looks like there was a statement issued on the 18th of March by the EMA safety committee: there is still no causal link between the vaccines and the clots and the frequency of clots in the study population is not more than one would expect in the general population. They still conclude the benefits outweigh the risks. — aporiap
It's a north american colloquialism and I'm not in an english class so I don't see the point of this unsolicited comment. — aporiap
It's possible and was discussed in the March 31st EMA update. We are still talking about a very low risk; in the 11 million AZ vaccinations across Europe assessed by EMA, there were 469 reports, only 26 of which were associated with low platelets [an essential feature of the VIPIT syndrome mediating the mechanism the Norwegian scientists were concerned about]. This risk is still orders of magnitude lower than one's risk of clotting with COVID.Both German and Norwegian scientists have identified a mechanism by which the Astra-Zeneca vaccine triggers an autoimmune response which can be fatal. In Norway 1 in 20,000 had serious side effects attributed to the vaccine.
I appreciate that, sometimes unsolicited corrections can be interpreted as a slight. I'll take your word on your helpful intention.Just in case you didn't know it's incorrect, like if I unsolicitedly tell you there's spinach in your teeth. I'm being helpful.
What's trail data? — frank
They tested it the same way the always test vaccines. You said it was lacking normal safety precautions. — frank
False equivalence. — tim wood
This the best I can do here. — tim wood
[Pharmaceutical companies] are incorporated to make money for their shareholders. — Isaac
This doesn't make the COVID-19 vaccine 'a tool for extracting money from the population' — Wayfarer
And yes, it's a criticism of capitalism as a whole — Isaac
EMA update. We are still talking about a very low risk; in the 11 million AZ vaccinations across Europe assessed by EMA, there were 469 reports, only 26 of which were associated with low platelets [an essential feature of the VIPIT syndrome mediating the mechanism the Norwegian scientists were concerned about]. This risk is still orders of magnitude lower than one's risk of clotting with COVID. — aporiap
It may be true that capitalism doesn’t have the best way of responding to this crisis, but what alternatives are there. — Wayfarer
From what you're mentioning now, that's a lot of risk being taken compared to vaccinating. It is of course up to you, but from a risk-taking standpoint I'd say it is a better choice to vaccinate in such a situation.I'm over 50, diabetic, heavy drinker for decades, daily contact with the public through work, living in an anti-science trumpy Republican backwater (Georgia) where public health measures are "optional". Risk factors as far as I can tell.
The worrisome mechanism they mention is termed Vaccine induced prothrombic thrombocytopenia. It is counterintuitive, but it is a syndrome characterized simultaneously by low platelets and thrombotic risk. From the EMA article, only 26 cases had thrombotic events with associated low platelets.I think you need to read that info a little more closely. Some people developed low platelets, some had thrombosis. — frank
I agree about not brushing it aside. It just needs to be taken into context of risk magnitude. To my understanding and as recommended by EMA, the prevalence of these events is very low and not more than one would expect by being a member of the general population and certainly lower than one would expect if actually infected with the virus. Since the frequency of occurrence is known and so low and since the benefits still outweigh the risk per EMA [which takes these and other important safety considerations into account when making such public recommendations], it's still valid to recommend taking the vaccine even as the mechanistic basis of some of these low frequency side effects are being investigated.This isn't the kind of thing we just brush aside. If we proceed with the AZ vaccine in some populations, we need to be able to tell people what the risks are and what signs to look for post treatment.
the risk of these events is very low and not more than one would expect by being a member of the general population and certainly lower than one would expect if actually infected with the virus. Since the frequency of occurrence is known and so low — aporiap
The worrisome mechanism they mention is termed Vaccine induced prothrombic thrombocytopenia. It is counterintuitive, but it is a syndrome characterized simultaneously by low platelets and thrombotic risk. From the EMA article, only 26 cases had thrombotic events with associated low platelets. — aporiap
. To my understanding and as recommended by EMA, the risk of these events is very low and not more than one would expect by being a member of the general population and certainly lower than one would expect if actually infected with the virus. — aporiap
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