To try and square the circle you’ve pointed out: one thing that I wanted to bring out with the focus on gene expression is that, to the degree that we take expression to be an exemplar of a living process, life itself must be thought of in processual terms. This is a fairly uncontroversial point in-itself, I hope: life is not a ‘thing’ but a process - or, in a less ‘dualizing’ approach: life is a ‘thing’ composed of processes (the language here is strained). But, and this is the crux, the peculiarity of the process is that it is neither biotic nor abiotic, but is, as it were, continuous between the two realms - in fact, such is the continuity that to speak of ‘two realms’ is already something of an after-the-fact projection: the process itself ‘doesn’t care’ about the rather arbitrary labels imposed upon the ‘elements’ involved. In principle, one could map the causal dynamics involved in gene expression without parsing the constituent elements into biotic and abiotic and do so
without any loss of information.
This indifference, I think, opens up a fascinating speculative possibility:
that life itself can be entirely divorced from the biotic. To pursue this thought in a different register, consider the following line of speculation from the evolutionary biologists Eva Jablonka and Marion Lamb, who envisage a possible future in which the DNA inheritance system is altogether replaced by higher-order one - and that, not only could this possibly happen, but that something like it might have
already happened with respect to our already existing DNA system:
"In existing organisms, which all have a nucleic acid–based inheritance system, it is inconceivable that the DNA inheritance system will be eliminated by another one that operates at a higher level. But theoretically it is possible that one heredity system can replace another. It may well have happened at an early stage in the evolution of life, during the murky period between chemical and biological evolution. Many theorists suggest that heredity during these early stages was not based on nucleic acids, and that the nucleic acid systems came later and replaced the primitive heredity systems. Maybe such a replacement will also occur in the distant future— if we create intelligent, reproducing, and evolving robots, they may eventually eliminate us. This would be equivalent to the elimination of one heredity system by another”. (Jablonka and Lamb,
Evolution in Four Dimensions)
J+L are here not talking of course, about gene expression but inheritance systems in evolution more generally, but the principle is the same: that life itself may be considered as something entirely separate from the biotic. Life would thus be a formal principle rather than a material one: so long as the process and its organisation are kept in place, the exact ‘instantiation’ of the formal principle is - from a very specific perspective - a matter of sheer indifference (I take inspiration also from Robert Rosen and Nicholas Rashevsky’s imperative to "throw away the matter and keep the underlying organisation”, when speaking about biological systems).
The final step here is to see that formal systems, by definition,
do not provide an index of their own applicability. That is, they simply say: ‘anything that meets these organisational criteria belong to the class of systems so named living’. But what does and does not count as ‘a’ thing here is not something that can be read off the phenomena itself: someone on a life support system might be said to be structurally coupled to that system, without which they would die: but the individuation of what counts and does not count here is a matter of judgement, not a matter of empirical study - hence the moral dilemmas we face when, in some circumstances, we decide on turning off a life support system or removing an breathing tube. Again, I’ve gone on too long and there’s still lots to say. But hope this fills out some possible gaps.