Can Life Have Meaning Without Afterlife?
Nothing in nature claims to be apart from everything except the human Self. It says "I am separated from the whole, I live here in my myself-bubble. I'm not even one with this body I'm inhabiting".
We may claim that we are all one but we don't (and we can't) experience oneness.
I don't think there's anything metaphysically wrong with the universe, rather the problem is the "I", the thinker and it's thoughts.
When there's no thinking there can be no problems. Nothing says "I am here now but one day I'll be gone". In between two thoughts there's no problem.
Can the Self be a product of human culture? Much like a few hundred years ago when basically everybody believed in God. Since you grew up surrounded by people constantly referring to this "God", he became "real".
The present day child has first no notion of a self, of a me, that is taught by repeatedly pointing and saying things like "yes you did that John!", "this is your teddy bear" and so on, repeatedly referring to the child's Self. Still it takes years until the child have self-produced thoughts (a Self).
So maybe the gurus are right, the self is an illusion?
(wow, this got off the track, sorry.)