Okay. First, this implies God. We cannot refrain from saying "God" because the fact is, we don't know what this "pre-existing condition" is. Ultimately, we will have to place the word "God" in our sentences in place of this unobservable and unknowable force behind the universe. I do not necessarily mean a "personal" god whatsoever. I am just stating the concept of agnosticism: a man shall not profess to know that which he has no scientific grounds for.

To give a short answer to your question of being able to derive a meaningful understanding of this unseen force, according to my experience and research, we can use the facts to rationalize and answer our questions. However, ultimately, science stops at the Big Bang. It is the job of metaphysics to answer what is behind all that exists. We have no definite evidence of how conditions in the early universe came to existence.

We have our limits and we can only go as far as we can. It would be interesting to consider, however, that in the process of our evolution, we may be able to generate enough information to form a complete unified theory of the universe and eradicate all divisions between science and religion.