Order from Disorder Jeremy England's theory of "dissipative-driven adaptation" is interesting step toward explaining abiogenesis, but probably still a bit of a hunch at the moment.
You might be able to conceive of a macroscopic analogue to a molecule, a bunch of sticks jointed together by springs, that has very interesting/dynamic behavior depending on how/where energy is introduced into it. The idea would be, whatever degrees of freedom the structure has, it reconfigures in such a way as to increase heat dissipation (but I don't really understand this).
Think about correctly holding a tuning fork. Depending on which handle we hold, determines how the input energy gets dissipated. It hums if one of its modes of vibration is not dissipated by holding the correct end. Maybe we could imagine some molecules as tuning forks, which act differently depending on how they got tethered/distributed in a solution/matter mix. Maybe when these molecules vibrate that actually cause some-kind of alignment of their neighbors, and thus the process of higher order self-assembly gets going... Energy from outside the system would drive oscillations that drives self-assembly.
Such configurations that become locked into dynamic cyclical processes may always require the flow of energy of a universe moving toward thermodynamic equilibrium.
The periodic table for instance is an amazing example of transient negantropy (structure), as the phenomenon of gravity has pushed hydrogen atoms into relatively (un)stable atomic configurations, through a process that has increased global entropy. The interplay of these differentiated atoms allow for some wild inorganic processes to occur, even before life could ever begin.
For instance, there is evidence in Gabon, Africa, of a cycle of natural fission during a time in Earth's history when Uranium-235 was in high enough natural concentrations to undergo a chain reaction. This natural atomic reactor required water (neutron moderator) to sustain the reaction. Sunlight no doubt played a part, as well the presence of an underground river, in delivering the water back to the fission site after it was evaporated. So here you have a very strange example of a unique cycle in the crust of the Earth, dependent on all kinds of just so structures (the special ashes of long dead stars bathed in the light of a living star).
Life is just another just so structure, on par with what we might consider less exciting stuff.