, the brain in a vat thought experiment doesn't involve senses as such, just some sort of sufficient stimuli (say, Matrix-style).
Phantom limbs, hallucinations and a few other things ^{(see below)} could perhaps serve as evidence.
Part of the thought experiment (hypothesis) is that the right simulation mechanics/gear could provide Armstrong (or just his gray matter) with sufficient stimuli that it'd be impossible for him to tell the difference, which seems somewhat conceivable (contra Mary's room).
Everything reducible to information and nothing else is another matter, though.
Is the question whether personal experiences and qualia (mind) is reducible to information in some sense?


_{Brain makes decisions before you even know it (Kerri Smith; Apr 2008)
Neural Decoding of Visual Imagery During Sleep (Horikawa, Tamaki, Miyawaki, Kamitani et al; May 2013)
Brain decoding: Reading minds (Kerri Smith; Oct 2013)
After 15 years in a vegetative state, nerve stimulation restores consciousness (Corazzol, Lio et al; Sep 2017)
Computer system transcribes words users “speak silently” (Larry Hardesty; Apr 2018)
Our brains reveal our choices before we're even aware of them, study finds (Lachlan Gilbert; Mar 2019)}

Pragmatism simply bypasses Descartes with a wry smile and no backward glance. — apokrisis

Yet, it's impossible to say more than "for all practical purposes".

Everything reducible to information and nothing else is another matter, though. — jorndoe

Will Neil Armstrong be able to tell the difference between a (highly detailed) moon simulation and the actual moon?

, if he can, then ...? If he can't, then ...?

if he can, then ...? If he can't, then ...? — jorndoe

If he can't then, all there is to reality is information and a simulation with the same information content as the actual is no different. If so, then Neil Armstrong achieves near-instantaneous travel between one place and another and that means his mind travels faster than light - mind is immaterial.

If he can, then there's more to reality than just information and Neil Armstrong's simulated moon experience is NOT the same as actually being on the moon and his mind can't achieve faster than light speed - mind is not immaterial.