The problem is weak philosophy - that is, subjective values. This leaves us in a hazy, nebulous, and clueless state, where the best we can do is live 'good but clueless lives' - not even knowing what 'good' is exactly.
I've answered all the Great Questions of Life adequately - my answers being based on current verified knowledge and our best models of reality (since my philosophy addresses broader survival), and I've even identified the REAL Greatest of the Great Questions of Life: "Why Bother?" (admit it - you must answer that question before you even begin to address the now 'lesser' questions - and note that science will never address that question - which means philosophy is still relevant (tell that to Stephen Hawking).
Answering this Greatest of the Great Questions of Life just happened to be the Ultimate Value of Life: Higher consciousness (of which humans are the current sole owners of (on Earth), though in a very primitive state). So to put the Greatest Answer into a sentence, the answer to "Why bother?" is "because consciousness is a good thing" (consider the alternative).
Now we have the Ultimate Value of Life, which has an associated Ultimate Goal - to secure the Ultimate Value (which currently happens to be unsecured). So in our case, the Ultimate Goal would be worded, "to secure higher consciousness in a harsh and deadly universe".
Now that we have an Ultimate Goal, we have an Ultimate Arbitrator in distinguishing good from evil (their being goal-driven), which gives us a solid foundation for building worthwhile lives (with a clue) and relevant civilizations (finally).
So now, when you are asked, "Why are you doing that?" "What is it you want?" "What are your motives?" You can put on a philosopher's hat and stand tall and say, "To secure higher consciousness in a harsh and deadly universe" (and you can add "thou fool!" just for impact).
The other "Great Questions of Life"? They have been answered by science in the form of verified knowledge (which is still largely ignored in favor of one's own uninformed imagination and social needs).
"Why are we here?" Verified Knowledge: "All evidence says there is no purpose. This is the universe that we have just awakened to. It is up to us to do with our awakening what we will."
"How did we come to exist?" Verified Knowledge: "All evidence points to pure chance in a chaos system of inanimate matter and energy."
"What is the meaning of life?" Verified Knowledge: "We make our own meaning, and if it is anything less than securing higher consciousness in a harsh and deadly universe, than you are a fool, a knave, or both, and your philosophy is death."
"Is there a God?" Verified Knowledge: "All evidence says 'no, and that all religions have been exposed as make-believe."
"Is there life after death?" Verified Knowledge: "All evidence says 'no', and further, it would be prudent to assume 'no' - that we have to work for it. Consider if we 'believed' that it existed and it did not, and we did not work for it, then we would be signing our death warrant.
"In the beginning, how did matter and energy come out of nothingness, i.e. how did 'something' come from 'nothing'?" This is a question for science, and it has not been answered yet. Philosophically I've answered it as follows: Infinity and eternity do not exist in the physical world, for anything that 'exists' needs 'bounds', and they are both 'boundless' - hence they are only words for 'nothingness'. Infinity is the nothingness in which everything exists, and eternity is the changelessness in which everything changes. The best we can do is define and broaden our time and space bounds in nothingness and changelessness (infinity and eternity), and hope that one day it intersects with other enlightened beings. Also, given infinity, 'everything' cannot exist (there being ever-more space for ever-more 'things' to exist in); and given eternity, 'eternal life' is rendered impossible (there being no end to stop and look back and say, 'Finally, I've lived forever!").
To finally address how 'something' came from 'nothing' - it can't, so the issue must be that there is something fundamentally wrong with our concepts of 'nothing' and 'something'... (and I suspect that infinity and eternity have something to do with it, but I of course can't be certain - it is a mere possibility to be further investigated).