It is inarguable to closed minds only. — praxis
It seems, perhaps you are not a serious person. This type of response tells me your mind is closed, and the surrounding thread makes it quite clear. Making claims in the face of opposing evidence is no reasonable, and not something that can be taken seriously on a forum like this.
It's only left to wonder how far Mill was right about social opinion being a restrictive, dictatorial aspect of group membership. The left has taken this to an extreme recently (the extreme left, obviously).
He was a culture war grifter and deliberatly cultivated social conflict for profit. — praxis
This is supported by nothing and could only make sense to someone who has only engaged with Charlie through a lens of left-wing, hateful rhetoric. Ironic, isn't it?
And of course you're persuaded by logical fallacies. — praxis
It seems you've decided to remove yourself from the adults table. That is fine by me.
I am not "charging you" with anything. I am pointing out that your own cite said there are more than two genotypes for this gene, and you think just asserting that there isn't is a refutation. — Mijin
So, that is, in fact, charging me with something (in this case, ignorance or perhaps manipulation). My own 'cite' did not say that. At all. And I have explained to you why, in detail: translocation is
not a genotype. I even gave you room to say that this is not what you mean. You have not. I presume it is what you mean. Translocation is not a third genotype.
There are not three genotypes for SRY. There are not three genotypes for SRY. There are not three genotypes for SRY. Go and ask ChatGPT (I don't want to just post a quote because you'll charge me with altering it). Go and put this prompt in "
are there three genotypes for SRY". I do not require an apology.
The only reason that we're discussing sex is because of the context of the gender discussion; your position seems to require asserting that the underlying sex is binary, and you're failing to find support for that assertion — Mijin
I've provided air-tight support for it. You moved back into talking about gender to get around it. We're not talking about gender. We are talking about sex. And in that context, you are point-blank wrong. Sex is a binary and is dimorphic in humans. We have two sexes and there are no exceptions. This is absolutely true, biologists agree, and you are not being serious with your responses here. I do not need you to agree - you are wrong. If you want to talk about gender we can, but this is in the context of whether it varies independently of sex (it does, so we're probably closer to the same page than you think there). Sex, though, is arguable binary. Let's go through it, based on your response here:
Cite please: an actual biologist, not your misreading of what chat gpt told you. — Mijin
*sigh* I
quoted ChatGPT. And I presumed you make this bad-faith move if I were to use ChatGPT further - but apparently - lo and behold you've
already made that move. That, as I'm sure you'll understand, makes it hard to take seriously.
https://www.researchgate.net/profile/Ken-Mcelreavey/publication/311361881_Mechanism_of_Sex_Determination_in_Humans_Insights_from_Disorders_of_Sex_Development/links/5d1c9bcd299bf1547c933773/Mechanism-of-Sex-Determination-in-Humans-Insights-from-Disorders-of-Sex-Development.pdf
This one is quite hard to grab on to because the point of the paper is not to illustrate that SRY is the determining factor. It implicitly accepts that it is, the entire way through, explaining how DSDs are
sex-specific. It is also kind of a boring paper.
Given that DSDs are sex-specific, they present no exception to and in fact reinforce the sex binary in humans, conceptually speaking. Even later genetic aberration cannot change one's sex - as will be apparent in this sources.
Here's another, clearer paper:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3701250/ and the most relevant section, with my commentary after:
"SRY is clearly important for the development of male sex, although in rare instances a
male phenotype can develop in its absence; but what is the genetic pathway by which SRY creates hormonally competent testes? This proved to be difficult to disentangle, despite the expectation that
once the Y-chromosomal male-determining gene was discovered, the elucidation of other genes following in the cascade from the bipotential gonadal rudiment to testis formation would quickly follow. Even after the discovery of further sex-determining genes, their relationship to SRY remains unknown. When a pathogenic mutation has been identified, the phenotypes can also be variable, even within the same family. It has been suggested that new genomic techniques might be required for better diagnoses of patients with disorders of sexual development. But might there be a simpler alternative pathway?"
To clarify the first italicised line, this is
clearly pointing out that males can have varying
phenotype. That means physical presentation. Not sex. Has nothing to do with whether one is male or female. Having a big nose is phenotypic. This is not news. This is not affecting sex determination.
The second line, then, gives us pretty robust indication that SRY is the sex-determining gene and that
further genetic information is secondary, as one would expect, to the determination of sex and instead relates to the
differentiation of sex.
here's some more;
https://www.nature.com/articles/348452a0?utm_ this one makes clear that SRY
must be active for male sex development to begin. The abstract is enough to grok this.
https://www.nature.com/articles/346240a0?utm_ - the original paper outlining SRY. Take that as you will, as we've come along way in 35 years.
https://pubmed.ncbi.nlm.nih.gov/1516467/ a cute line from the abstract here
"A strategy based on determining the precise chromosomal location of this locus has been used to clone a new gene which has been called SRY in humans (Sry in mice). A variety of studies now show that this is indeed the testis-determining gene."
https://link.springer.com/article/10.1007/s44162-023-00025-8?utm_ and this one, from the short conclusion:
"The peculiar translocation of the SRY gene in
46,XX males strongly supports the inclusion of cytogenetic testing for establishing diagnosis and genetic counseling for infertility and/or hormonal imbalances in individuals."
Males.
And for a bit of a slam-dunk here:
https://www.ncbi.nlm.nih.gov/books/NBK22246/?utm_
"Most XX men who lack a Y chromosome do still have a copy of the SRY region on one of their X chromosomes. This copy accounts for their maleness."
All of this clearly shows a relatively stable consensus in the biological literature that SRY is the sex-determining gene and that DSDs are sex-specific. This really isn't a debate.
Just an aside, anyone calling Kathleen Stock anything but principled, forthright and courageous is looking into a void and seeing what they want to.